|Application ||WB, E|
|Other Accession||Q8CCI5, NP_036366.3|
|Calculated MW||24822 Da|
|Antigen Region||1-30 aa|
|Other Names||RING1 and YY1-binding protein, Apoptin-associating protein 1, APAP-1, Death effector domain-associated factor, DED-associated factor, YY1 and E4TF1-associated factor 1, RYBP, DEDAF, YEAF1|
|Target/Specificity||This RYBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RYBP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RYBP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.|
|Cellular Location||Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity).|
|Tissue Location||Widely expressed with highest levels in lymphoid tissues and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
RYBP may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Chen, D., et al. EMBO Rep. 10(2):166-172(2009)
Novak, R.L., et al. Cancer Gene Ther. 15(11):713-722(2008)
Danen-van Oorschot, A.A., et al. Cell Death Differ. 11(5):564-573(2004)
Guelen, L., et al. Oncogene 23(5):1153-1165(2004)
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