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BCAS1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BCAS1 Antibody (N-term) AP16632a
    BCAS1 Antibody (N-term) (Cat. #AP16632a) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the BCAS1 antibody detected the BCAS1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75363
Other Accession NP_003648.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 1-30 aa
Additional Information
Other Names Breast carcinoma-amplified sequence 1, Amplified and overexpressed in breast cancer, Novel amplified in breast cancer 1, BCAS1, AIBC1, NABC1
Target/Specificity This BCAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BCAS1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBCAS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCAS1
Synonyms AIBC1, NABC1
Cellular Location Cytoplasm.
Tissue Location Expressed in brain and prostate, and at lower levels in testis, intestine and colon. Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors. EMBL; AF041260; AAC39896.1; -; mRNA EMBL; AC004501; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC005220; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC126346; AAI26347.1; -; mRNA EMBL; AI904532; -; NOT_ANNOTATED_CDS; mRNA EMBL; CR749643; CAH18437.1; -; mRNA CCDS; CCDS13444.1; -. [O75363-1] RefSeq; NP_003648.2; NM_003657.3. [O75363-1] UniGene; Hs.400556; - ProteinModelPortal; O75363; - BioGrid; 114107; 3 STRING; 9606.ENSP00000379290; - iPTMnet; O75363; - PhosphoSitePlus; O75363; - BioMuta; BCAS1; - MaxQB; O75363; - PaxDb; O75363; - PeptideAtlas; O75363; - PRIDE; O75363; - DNASU; 8537; - Ensembl; ENST00000395961; ENSP00000379290; ENSG00000064787. [O75363-1] GeneID; 8537; - KEGG; hsa:8537; - UCSC; uc002xws.3; human. [O75363-1] CTD; 8537; - DisGeNET; 8537; - GeneCards; BCAS1; - H-InvDB; HIX0015925; - HGNC; HGNC:974; BCAS1 HPA; CAB033558; - HPA; HPA051816; - HPA; HPA054745; - MIM; 602968; gene neXtProt; NX_O75363; - OpenTargets; ENSG00000064787; - PharmGKB; PA25284; - eggNOG; ENOG410IJ5W; Eukaryota eggNOG; ENOG41119UT; LUCA GeneTree; ENSGT00390000003167; - HOGENOM; HOG000232037; - HOVERGEN; HBG082347; - InParanoid; O75363; - OMA; TQGAAKN; - OrthoDB; EOG091G07RJ; - PhylomeDB; O75363; - TreeFam; TF335555; - BioCyc; ZFISH:ENSG00000064787-MONOMER; - ChiTaRS; BCAS1; human GeneWiki; BCAS1; - GenomeRNAi; 8537; - PRO; PR:O75363; - Proteomes; UP000005640; Chromosome 20 Bgee; ENSG00000064787; - CleanEx; HS_BCAS1; - ExpressionAtlas; O75363; baseline and differential Genevisible; O75363; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB InterPro; IPR026115; NABC1 PANTHER; PTHR15016; PTHR15016; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome CHAIN 1 584 Breast carcinoma-amplified sequence 1 /FTId=PRO_0000064859 MOD_RES 124 124 Phosphoserine {ECO:0000250|UniProtKB:Q3ZB98} MOD_RES 192 192 Phosphoserine {ECO:0000250|UniProtKB:Q3ZB98} MOD_RES 314 314 Phosphoserine {ECO:0000250|UniProtKB:Q3ZB98} MOD_RES 381 381 Phosphoserine {ECO:0000250|UniProtKB:Q80YN3} MOD_RES 399 399 Phosphoserine {ECO:0000250|UniProtKB:Q80YN3} MOD_RES 480 480 Phosphothreonine {ECO:0000250|UniProtKB:Q80YN3} MOD_RES 552 552 Phosphoserine {ECO:0000250|UniProtKB:Q3ZB98} VAR_SEQ 309 309 T -> TASKAESVCDGQAGQKTSEIQARGTKKKHLDSPRLG LAFRKFFRHK (in isoform 2) /FTId=VSP_018520 VAR_SEQ 381 394 Missing (in isoform 2) /FTId=VSP_018521 VAR_SEQ 451 472 Missing (in isoform 2) /FTId=VSP_018522 VAR_SEQ 584 584 K -> KYTGKCVFSHVKKKWPFQEWSY (in isoform 2). /FTId=VSP_018523 VARIANT 24 24 Q -> K (in dbSNP:rs394732) /FTId=VAR_026674 VARIANT 163 163 V -> A (in dbSNP:rs158551) /FTId=VAR_026675 VARIANT 255 255 G -> E (in dbSNP:rs6022903) /FTId=VAR_024251 VARIANT 472 472 Q -> H (in dbSNP:rs35575210) /FTId=VAR_050691 VARIANT 583 583 S -> P (in dbSNP:rs1055246) /FTId=VAR_026676 CONFLICT 361 361 G -> D (in Ref. 5; CAH18437) SEQUENCE 584 AA; 61709 MW; 22921C0B37129944 CRC64; MGNQMSVPQR VEDQENEPEA ETYQDNASAL NGVPVVVSTH TVQHLEEVDL GISVKTDNVA TSSPETTEIS AVADANGKNL GKEAKPEAPA AKSRFFLMLS RPVPGRTGDQ AADSSLGSVK LDVSSNKAPA NKDPSESWTL PVAAGPGQDT DKTPGHAPAQ DKVLSAARDP TLLPPETGGA GGEAPSKPKD SSFFDKFFKL DKGQEKVPGD SQQEAKRAEH QDKVDEVPGL SGQSDDVPAG KDIVDGKEKE GQELGTADCS VPGDPEGLET AKDDSQAAAI AENNNSIMSF FKTLVSPNKA ETKKDPEDTG AEKSPTTSAD LKSDKANFTS QETQGAGKNS KGCNPSGHTQ SVTTPEPAKE GTKEKSGPTS LPLGKLFWKK SVKEDSVPTG AEENVVCESP VEIIKSKEVE SALQTVDLNE GDAAPEPTEA KLKREESKPR TSLMAFLRQM SVKGDGGITH SEEINGKDSS CQTSDSTEKT ITPPEPEPTG APQKGKEGSS KDKKSAAEMN KQKSNKQEAK EPAQCTEQAT VDTNSLQNGD KLQKRPEKRQ QSLGGFFKGL GPKRMLDAQV QTDPVSIGPV GKSK
Citations (0)

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This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene.


Rose, J. Phd, et al. Mol. Med. (2010) In press :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Burmester, J.K., et al. Hum. Hered. 57(4):172-178(2004)
Beardsley, D.I., et al. Exp. Cell Res. 290(2):402-413(2003)
Deloukas, P., et al. Nature 414(6866):865-871(2001)

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Cat# AP16632a
(40 western blots)
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