BCAS1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | O75363 |
Other Accession | NP_003648.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 61709 Da |
Antigen Region | 1-30 aa |
Gene ID | 8537 |
---|---|
Other Names | Breast carcinoma-amplified sequence 1, Amplified and overexpressed in breast cancer, Novel amplified in breast cancer 1, BCAS1, AIBC1, NABC1 |
Target/Specificity | This BCAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BCAS1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BCAS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BCAS1 |
---|---|
Synonyms | AIBC1, NABC1 |
Function | Required for myelination. |
Cellular Location | Cytoplasm. |
Tissue Location | Highly expressed in the brain and, more specifically, in oligodendrocytes (at protein level). Expressed in the prostate, and at lower levels in testis, intestine and colon Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Burmester, J.K., et al. Hum. Hered. 57(4):172-178(2004)
Beardsley, D.I., et al. Exp. Cell Res. 290(2):402-413(2003)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.