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BCAS1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BCAS1 Antibody (N-term) AP16632a
    BCAS1 Antibody (N-term) (Cat. #AP16632a) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the BCAS1 antibody detected the BCAS1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O75363
Other Accession NP_003648.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 61709 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 8537
Other Names Breast carcinoma-amplified sequence 1, Amplified and overexpressed in breast cancer, Novel amplified in breast cancer 1, BCAS1, AIBC1, NABC1
Target/Specificity This BCAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BCAS1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBCAS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCAS1
Synonyms AIBC1, NABC1
Function Required for myelination.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in the brain and, more specifically, in oligodendrocytes (at protein level). Expressed in the prostate, and at lower levels in testis, intestine and colon Overexpressed in most breast cancer cell lines and down-regulated in some colorectal tumors.
Citations (0)
citation

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Background

This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Burmester, J.K., et al. Hum. Hered. 57(4):172-178(2004)
Beardsley, D.I., et al. Exp. Cell Res. 290(2):402-413(2003)
Deloukas, P., et al. Nature 414(6866):865-871(2001)

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$ 182.50
$ 70.00
Cat# AP16632a
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