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RNF34 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP16633b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP16633b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
RNF34 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q969K3 |
| Other Accession | Q6AYH3, Q99KR6, Q5E9J6, NP_079402.2, NP_919247.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 41641 Da |
RNF34 Antibody (C-term) - Additional info | |
| Gene ID 80196 | |
| Other Names RNF34; E3 ubiquitin-protein ligase RNF34; Caspase regulator CARP1; Caspases-8 and -10-associated RING finger protein 1; FYVE-RING finger protein Momo; Human RING finger homologous to inhibitor of apoptosis protein; RING finger protein 34; RING finger protein RIFF | |
| Target/Specificity This RNF34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-311 amino acids from the C-terminal region of human RNF34. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions RNF34 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
RNF34 Antibody (C-term) - Protein Information | |
| Name RNF34 | |
| Function Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3- phosphate | |
| Cellular Location Nucleus speckle. Endomembrane system; Peripheral membrane protein | |
| Tissue Location Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes | |
RNF34 Antibody (C-term) - Related products
AP16633b: RNF34 Antibody (C-term)
RNF34 Antibody (C-term) - Application data
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RNF34 Antibody (C-term) (Cat. #AP16633b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the RNF34 antibody detected the RNF34 protein (arrow).
RNF34 Antibody (C-term) - Research Areas
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BACKGROUND
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
REFERENCES
Erlbruch, A., et al. Proteomics 10(16):2890-2900(2010) Yang, W., et al. Cell Cycle 7(5):670-682(2008) Yang, W., et al. J. Biol. Chem. 282(5):3273-3281(2007) Konishi, T., et al. Mol. Cancer Ther. 4(5):743-750(2005) Sasaki, S., et al. J. Exp. Clin. Cancer Res. 23(3):507-512(2004)
