|Application ||WB, E|
|Other Accession||NP_001153715.1, NP_001028174.2|
|Calculated MW||24784 Da|
|Antigen Region||16-44 aa|
|Other Names||RPA-interacting protein, hRIP, RPAIN, RIP|
|Target/Specificity||This RPAIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-44 amino acids from the N-terminal region of human RPAIN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RPAIN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.|
|Cellular Location||Isoform 1: Cytoplasm. Nucleus.|
|Tissue Location||Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen|
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Provided below are standard protocols that you may find useful for product applications.
RPAIN mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Dagle, J.M., et al. Pediatrics 123(4):1116-1123(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Park, J., et al. Mol. Cell. Biol. 25(18):8202-8214(2005)
Chen, J.Z., et al. DNA Cell Biol. 24(7):464-469(2005)
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