|Application ||WB, E|
|Calculated MW||82995 Da|
|Antigen Region||74-102 aa|
|Other Names||RB-associated KRAB zinc finger protein, RB-associated KRAB repressor, hRBaK, Zinc finger protein 769, RBAK, ZNF769|
|Target/Specificity||This RBAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-102 amino acids from the N-terminal region of human RBAK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RBAK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May repress E2F-dependent transcription. May promote AR- dependent transcription.|
|Tissue Location||Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif.
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Ma, Y., et al. BMC Genomics 10, 109 (2009) :
Jeske, Y.W., et al. Clin. Exp. Pharmacol. Physiol. 35(4):380-385(2008)
So, A., et al. Clin. Endocrinol. (Oxf) 65(6):829-831(2006)
Vertegaal, A.C., et al. Mol. Cell Proteomics 5(12):2298-2310(2006)
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