RBAK Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9NYW8 |
Other Accession | NP_066986.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 82995 Da |
Antigen Region | 74-102 aa |
Gene ID | 57786 |
---|---|
Other Names | RB-associated KRAB zinc finger protein, RB-associated KRAB repressor, hRBaK, Zinc finger protein 769, RBAK, ZNF769 |
Target/Specificity | This RBAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-102 amino acids from the N-terminal region of human RBAK. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RBAK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RBAK |
---|---|
Synonyms | ZNF769 |
Function | May repress E2F-dependent transcription. May promote AR- dependent transcription. |
Cellular Location | Nucleus. |
Tissue Location | Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif.
References
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Ma, Y., et al. BMC Genomics 10, 109 (2009) :
Jeske, Y.W., et al. Clin. Exp. Pharmacol. Physiol. 35(4):380-385(2008)
So, A., et al. Clin. Endocrinol. (Oxf) 65(6):829-831(2006)
Vertegaal, A.C., et al. Mol. Cell Proteomics 5(12):2298-2310(2006)
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