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ACSL3 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP16647b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP16647b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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ACSL3 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | O95573 |
| Other Accession | Q63151, NP_976251.1, NP_004448.2 |
| Reactivity | Human |
| Predicted | Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 80420 Da |
ACSL3 Antibody (C-term) - Additional info | |
| Gene ID 2181 | |
| Other Names ACSL3; ACS3; FACL3; LACS3; Long-chain-fatty-acid--CoA ligase 3; Long-chain acyl-CoA synthetase 3 | |
| Target/Specificity This ACSL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-556 amino acids from the C-terminal region of human ACSL3. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACSL3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACSL3 Antibody (C-term) - Protein Information | |
| Name ACSL3 | |
| Synonyms ACS3, FACL3, LACS3 | |
| Function Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) | |
| Cellular Location Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity) Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity) | |
ACSL3 Antibody (C-term) - Related products
AP16647b: ACSL3 Antibody (C-term)
AP2535a: ACSL3 (FACL3) Antibody (N-term)
ACSL3 Antibody (C-term) - Application data
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ACSL3 Antibody (C-term) (Cat. #AP16647b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ACSL3 antibody detected the ACSL3 protein (arrow).
ACSL3 Antibody (C-term) - Research Areas
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BACKGROUND
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.
REFERENCES
Weedon-Fekjaer, M.S., et al. J. Lipid Res. 51(7):1886-1896(2010) Cao, A., et al. J. Biol. Chem. 285(22):16664-16674(2010) Perera, F., et al. PLoS ONE 4 (2), E4488 (2009) : Yao, H., et al. J. Biol. Chem. 283(2):849-854(2008) Jia, Z., et al. J. Mol. Neurosci. 33(1):25-31(2007)
