|Application ||WB, E|
|Other Accession||NP_060425.2, NP_663747.1|
|Calculated MW||26114 Da|
|Antigen Region||163-190 aa|
|Other Names||Cell division cycle-associated protein 4, Hematopoietic progenitor protein, CDCA4, HEPP|
|Target/Specificity||This CDCA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-190 amino acids from the C-terminal region of human CDCA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDCA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).|
|Tissue Location||Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon. Hardly detectable, if at all, in the brain, skeletal muscle and heart.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.
Tategu, M., et al. Biochimie 90(10):1515-1522(2008)
Wang, L., et al. Cell Motil. Cytoskeleton 65(7):581-593(2008)
Hayashi, R., et al. J. Biol. Chem. 281(47):35633-35648(2006)
Walker, M.G. Curr Cancer Drug Targets 1(1):73-83(2001)
Abdullah, J.M., et al. Blood Cells Mol. Dis. 27(3):667-676(2001)
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