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CDCA4 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CDCA4 Antibody (C-term) AP16652b
    CDCA4 Antibody (C-term) (Cat. #AP16652b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CDCA4 antibody detected the CDCA4 protein (arrow).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BXL8
Other Accession NP_060425.2, NP_663747.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 26114 Da
Antigen Region 163-190 aa
Additional Information
Gene ID 55038
Other Names Cell division cycle-associated protein 4, Hematopoietic progenitor protein, CDCA4, HEPP
Target/Specificity This CDCA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-190 amino acids from the C-terminal region of human CDCA4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDCA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDCA4
Synonyms HEPP
Function May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity).
Cellular Location Nucleus.
Tissue Location Highest levels of expression in the pancreas, thymus, testis, spleen, liver, placenta and leukocytes. Relatively low levels in the lung, kidney, prostate, ovary, small intestine and colon Hardly detectable, if at all, in the brain, skeletal muscle and heart
Research Areas
Citations (0)
citation

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Background

This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.

References

Tategu, M., et al. Biochimie 90(10):1515-1522(2008)
Wang, L., et al. Cell Motil. Cytoskeleton 65(7):581-593(2008)
Hayashi, R., et al. J. Biol. Chem. 281(47):35633-35648(2006)
Walker, M.G. Curr Cancer Drug Targets 1(1):73-83(2001)
Abdullah, J.M., et al. Blood Cells Mol. Dis. 27(3):667-676(2001)

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$ 182.50
$ 70.00
Cat# AP16652b
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