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GPN1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HCN4 |
| Other Accession | NP_001138520.1, NP_001138519.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41740 Da |
| Antigen Region | 325-352 aa |
| Gene ID | 11321 |
|---|---|
| Other Names | GPN-loop GTPase 1, 365-, MBD2-interacting protein, MBDin, RNAPII-associated protein 4, XPA-binding protein 1, GPN1 {ECO:0000303|PubMed:20855544, ECO:0000312|HGNC:HGNC:17030} |
| Target/Specificity | This GPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 325-352 amino acids from the C-terminal region of human GPN1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPN1 {ECO:0000303|PubMed:20855544, ECO:0000312|HGNC:HGNC:17030} |
|---|---|
| Function | Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). |
| Cellular Location | Cytoplasm. Nucleus Note=Shuttles between the nucleus and the cytoplasm |
| Tissue Location | Expressed ubiquitously. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described.
References
Lembo, F., et al. Mol. Cell. Biol. 23(5):1656-1665(2003)
Nitta, M., et al. Nucleic Acids Res. 28(21):4212-4218(2000)
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