ZNF263 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O14978 |
Other Accession | NP_005732.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 77299 Da |
Antigen Region | 318-346 aa |
Gene ID | 10127 |
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Other Names | Zinc finger protein 263, Zinc finger protein FPM315, Zinc finger protein with KRAB and SCAN domains 12, ZNF263, FPM315, ZKSCAN12 |
Target/Specificity | This ZNF263 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-346 amino acids from the Central region of human ZNF263. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZNF263 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZNF263 (HGNC:13056) |
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Function | Transcription factor that binds to the consensus sequence 5'- TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030). |
Cellular Location | Nucleus. |
Tissue Location | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZNF263 might play an important role in basic cellular processes as a transcriptional repressor.
References
Frietze, S., et al. J. Biol. Chem. 285(2):1393-1403(2010)
Martin, J., et al. Nature 432(7020):988-994(2004)
Yokoyama, M., et al. Biochim. Biophys. Acta 1353(1):13-17(1997)
Okubo, K., et al. Genomics 30(2):178-186(1995)
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