|Application ||WB, E|
|Other Accession||Q9JKQ4, NP_005844.4|
|Calculated MW||50361 Da|
|Antigen Region||455-483 aa|
|Other Names||Iroquois-class homeodomain protein IRX-5, Homeodomain protein IRX-2A, Homeodomain protein IRXB2, Iroquois homeobox protein 5, IRX5, IRX2A, IRXB2|
|Target/Specificity||This IRX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 455-483 amino acids from the C-terminal region of human IRX5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IRX5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
IRX5 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
Myrthue, A., et al. Clin. Cancer Res. 14(11):3562-3570(2008)
Bruneau, B.G. Med Sci (Paris) 22(3):231-232(2006)
Ogura, K., et al. Cytogenet. Cell Genet. 92 (3-4), 320-325 (2001) :
Lewis, M.T., et al. Cell Tissue Res. 296(3):549-554(1999)
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