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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TNIP2 Antibody (Center)   

TNIP2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TNIP2 Antibody (Center) AP16658c
    TNIP2 Antibody (Center) (Cat. #AP16658c) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TNIP2 antibody detected the TNIP2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NFZ5
Other Accession NP_001154999.1, NP_077285.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48700 Da
Antigen Region 165-194 aa
Additional Information
Gene ID 79155
Other Names TNFAIP3-interacting protein 2, A20-binding inhibitor of NF-kappa-B activation 2, ABIN-2, Fetal liver LKB1-interacting protein, TNIP2 {ECO:0000312|EMBL:EAW825141}
Target/Specificity This TNIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the Central region of human TNIP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNIP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNIP2 {ECO:0000312|EMBL:EAW82514.1}
Function Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Cellular Location Cytoplasm. Nucleus
Tissue Location Ubiquitously expressed in all tissues examined.
Research Areas
Citations (0)

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TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3; MIM 191163) and is involved in activation of the ERK (see MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001 [PubMed 11390377]; Papoutsopoulou et al., 2006 [PubMed 16633345]).


Raychaudhuri, S., et al. Nat. Genet. 41(12):1313-1318(2009)
Handoyo, H., et al. Biochem. J. 424(1):109-118(2009)
Verstrepen, L., et al. Biochem. Pharmacol. 78(2):105-114(2009)
Huang, L., et al. Oncogene 27(47):6131-6140(2008)
Liu, Y., et al. J. Radiat. Res. 48(1):13-20(2007)

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$ 295.00
$ 99.00
Cat# AP16658c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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