|Application ||WB, E|
|Calculated MW||97402 Da|
|Antigen Region||343-372 aa|
|Other Names||NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5-like, Nlrp6, Nalp6, Pypaf5|
|Target/Specificity||This Mouse Nlrp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-372 amino acids from the Central region of mouse Nlrp6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Nlrp6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Isoform 1 binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Isoform 2 binds both arginine- vasopressin and angiotensin II and acts as an angiotensin II/vasopressin receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation.|
|Cellular Location||Isoform 1: Cytoplasm. Cell membrane. Nucleus membrane|
|Tissue Location||Highly expressed in the small and large intestine, kidney and liver.|
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Nlrp6 may mediate activation of CASP1 via ASC and promote activation of NF-kappa-B (By similarity).
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