|Application ||WB, IF, IHC-P, FC, E|
|Other Accession||P41160, NP_000221.1|
|Calculated MW||18641 Da|
|Antigen Region||8-37 aa|
|Other Names||Leptin, Obese protein, Obesity factor, LEP, OB, OBS|
|Target/Specificity||This LEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human LEP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LEP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq].
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Qin, J., et al. J. Hum. Genet. 55(10):704-706(2010)
Friedlander, Y., et al. Ann. Hum. Genet. 74(5):387-398(2010)
Sarzynski, M.A., et al. Int J Obes (Lond) (2010) In press :
Iciek, R., et al. Ginekol. Pol. 81(8):571-577(2010)
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