|Application ||WB, E|
|Calculated MW||37377 Da|
|Antigen Region||111-139 aa|
|Other Names||3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1|
|Target/Specificity||This AKR1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the Central region of human AKR1D1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AKR1D1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates.|
|Tissue Location||Highly expressed in liver. Expressed in testis and weakly in colon.|
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Provided below are standard protocols that you may find useful for product applications.
The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.
Steen, N.E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :
Drury, J.E., et al. J. Biol. Chem. 285(32):24529-24537(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ueki, I., et al. J. Gastroenterol. Hepatol. 24(5):776-785(2009)
Panagopoulos, I., et al. Oncol. Rep. 21(3):615-624(2009)
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