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AKR1D1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AKR1D1 Antibody (Center) AP16670C
    AKR1D1 Antibody (Center) (Cat. #AP16670c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AKR1D1 antibody detected the AKR1D1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51857
Other Accession NP_005980.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 37377 Da
Antigen Region 111-139 aa
Additional Information
Gene ID 6718
Other Names 3-oxo-5-beta-steroid 4-dehydrogenase, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, Delta(4)-3-oxosteroid 5-beta-reductase, AKR1D1, SRD5B1
Target/Specificity This AKR1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the Central region of human AKR1D1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAKR1D1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR1D1
Synonyms SRD5B1
Function Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in liver. Expressed in testis and weakly in colon.
Research Areas
Citations (0)

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The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet.


Steen, N.E., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry (2010) In press :
Drury, J.E., et al. J. Biol. Chem. 285(32):24529-24537(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ueki, I., et al. J. Gastroenterol. Hepatol. 24(5):776-785(2009)
Panagopoulos, I., et al. Oncol. Rep. 21(3):615-624(2009)

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$ 295.00
$ 99.00
Cat# AP16670C
(40 western blots)
Availability: In Stock
Bulk Size
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