|Application ||WB, E|
|Other Accession||P97376, NP_004468.1|
|Calculated MW||29172 Da|
|Antigen Region||230-256 aa|
|Other Names||Protein FRG1, FSHD region gene 1 protein, FRG1|
|Target/Specificity||This FRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-256 amino acids from the C-terminal region of human FRG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FRG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N- methyltransferase KMT5B.|
|Cellular Location||Nucleus, Cajal body Nucleus, nucleolus Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line. Note=Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post-differentiation (PubMed:20970242) Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation (PubMed:20970242)|
|Tissue Location||Expressed in adult muscle, lymphocytes, fetal brain, muscle, and placenta. Also expressed in the smooth muscle of arteries and veins, the sweat glands and the epidermis|
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Provided below are standard protocols that you may find useful for product applications.
This gene maps to a location 100 kb centromeric of the repeat units on chromosome 4q35 which are deleted in facioscapulohumeral muscular dystrophy (FSHD). It is evolutionarily conserved and has related sequences on multiple human chromosomes but DNA sequence analysis did not reveal any homology to known genes. In vivo studies demonstrate the encoded protein is localized to the nucleolus.
Hanel, M.L., et al. Dev. Dyn. 238(6):1502-1512(2009)
Bodega, B., et al. BMC Biol. 7, 41 (2009) :
Pirozhkova, I., et al. PLoS ONE 3 (10), E3389 (2008) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Gabellini, D., et al. Nature 439(7079):973-977(2006)
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