|Application ||WB, E|
|Other Accession||NP_001116153.1, NP_001139327.1|
|Calculated MW||62244 Da|
|Antigen Region||151-180 aa|
|Other Names||SH3 domain-binding protein 2, 3BP-2, SH3BP2, 3BP2|
|Target/Specificity||This SH3BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human SH3BP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SH3BP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.|
|Tissue Location||Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
Lietman, S.A., et al. J. Orthop. Res. 28(11):1425-1430(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Amaral, F.R., et al. J. Oral Pathol. Med. 39(3):269-274(2010)
Shukla, U., et al. J. Biol. Chem. 284(49):33719-33728(2009)
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