|Application ||WB, E|
|Calculated MW||44836 Da|
|Antigen Region||138-167 aa|
|Other Names||Alpha-2, 8-sialyltransferase 8F, 2499-, Sialyltransferase 8F, SIAT8-F, Sialyltransferase St8Sia VI, ST8SiaVI, ST8SIA6, SIAT8F|
|Target/Specificity||This ST8SIA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of human ST8SIA6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ST8SIA6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc- alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity).|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 220.127.116.11) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).
Yang, J.J., et al. JAMA 301(4):393-403(2009)
Avril, T., et al. J. Leukoc. Biol. 80(4):787-796(2006)
Harduin-Lepers, A., et al. Glycobiology 15(8):805-817(2005)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Takashima, S., et al. J. Biol. Chem. 277(27):24030-24038(2002)
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