ST8SIA6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P61647 |
Other Accession | NP_001004470.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44836 Da |
Antigen Region | 138-167 aa |
Gene ID | 338596 |
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Other Names | Alpha-2, 8-sialyltransferase 8F, 2499-, Sialyltransferase 8F, SIAT8-F, Sialyltransferase St8Sia VI, ST8SiaVI, ST8SIA6, SIAT8F |
Target/Specificity | This ST8SIA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of human ST8SIA6. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ST8SIA6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ST8SIA6 (HGNC:23317) |
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Synonyms | SIAT8F |
Function | Alpha-2,8-sialyltransferase that prefers O-glycans to N- glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups. |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sialic acid is a key determinate of oligosaccharide structures involved in cell-cell communication, cell-substrate interaction, adhesion, and protein targeting. ST8SIA6 belongs to a family of sialyltransferases (EC 2.4.99.8) that synthesize sialylglycoconjugates (Takashima et al., 2002 [PubMed 11980897]).
References
Yang, J.J., et al. JAMA 301(4):393-403(2009)
Avril, T., et al. J. Leukoc. Biol. 80(4):787-796(2006)
Harduin-Lepers, A., et al. Glycobiology 15(8):805-817(2005)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Takashima, S., et al. J. Biol. Chem. 277(27):24030-24038(2002)
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