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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EPOR Antibody (Center)   

EPOR Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EPOR Antibody (Center) AP16681c
    EPOR Antibody (Center) (Cat. #AP16681c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the EPOR antibody detected the EPOR protein (arrow).
  • FC - EPOR Antibody (Center) AP16681c
    EPOR Antibody (Center) (Cat. #AP16681c) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IF - EPOR Antibody (Center) AP16681c
    Confocal immunofluorescent analysis of EPOR Antibody (Center)(Cat#AP16681c) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19235
Other Accession NP_000112.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 55065 Da
Antigen Region 329-357 aa
Additional Information
Gene ID 2057
Other Names Erythropoietin receptor, EPO-R, EPOR
Target/Specificity This EPOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-357 amino acids from the Central region of human EPOR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEPOR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells
Research Areas
Citations (0)

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This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.


Lim, A.C., et al. Biochemistry 49(18):3797-3804(2010)
Perrotta, S., et al. PLoS ONE 5 (8), E12015 (2010) :
Khankin, E.V., et al. PLoS ONE 5 (2), E9246 (2010) :
Wincewicz, A., et al. Folia Histochem. Cytobiol. 47(3):425-430(2009)
Ketteler, R., et al. J. Biol. Chem. 278(4):2654-2660(2003)

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$ 295.00
$ 99.00
Cat# AP16681c
(40 western blots)
Availability: In Stock
Bulk Size
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