LPAR4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q99677 |
Other Accession | Q8BLG2, NP_005287.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 41895 Da |
Antigen Region | 127-156 aa |
Gene ID | 2846 |
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Other Names | Lysophosphatidic acid receptor 4, LPA receptor 4, LPA-4, G-protein coupled receptor 23, P2Y purinoceptor 9, P2Y9, P2Y5-like receptor, Purinergic receptor 9, LPAR4, GPR23, LPA4, P2RY9 |
Target/Specificity | This LPAR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the Central region of human LPAR4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | LPAR4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | LPAR4 |
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Synonyms | GPR23, LPA4, P2RY9 |
Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1- oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1- alkenyl-LPA. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation.
References
Liu, Y.B., et al. J. Cell. Biochem. 109(4):794-800(2010)
Kumar, S.A., et al. Leuk. Lymphoma 50(12):2038-2048(2009)
Luttrell, L.M. Mol. Biotechnol. 39(3):239-264(2008)
Dowal, L., et al. J. Biol. Chem. 281(33):23999-24014(2006)
Noguchi, K., et al. J. Biol. Chem. 278(28):25600-25606(2003)
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