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SPEM1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SPEM1 Antibody (Center) AP16687c
    SPEM1 Antibody (Center) (Cat. #AP16687c) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the SPEM1 antibody detected the SPEM1 protein (arrow).
  • WB - SPEM1 Antibody (Center) AP16687c
    Western blot analysis of SPEM1 (arrow) using rabbit polyclonal SPEM1 Antibody (Center) (Cat. #AP16687c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SPEM1 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N4L4
Other Accession NP_955371.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 115-143 aa
Additional Information
Other Names Spermatid maturation protein 1, SPEM1, C17orf83
Target/Specificity This SPEM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human SPEM1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPEM1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPEM1
Synonyms C17orf83
Function Required for proper cytoplasm removal during spermatogenesis.
Cellular Location Membrane; Single-pass membrane protein. Cytoplasm EMBL; BC033882; AAH33882.1; -; mRNA CCDS; CCDS42254.1; - RefSeq; NP_955371.2; NM_199339.2 UniGene; Hs.710599; - ProteinModelPortal; Q8N4L4; - BioGrid; 131920; 2 IntAct; Q8N4L4; 1 STRING; 9606.ENSP00000315554; - iPTMnet; Q8N4L4; - PhosphoSitePlus; Q8N4L4; - BioMuta; SPEM1; - DMDM; 74728870; - PaxDb; Q8N4L4; - PeptideAtlas; Q8N4L4; - PRIDE; Q8N4L4; - ProteomicsDB; 71940; - Ensembl; ENST00000323675; ENSP00000315554; ENSG00000181323 Ensembl; ENST00000640564; ENSP00000492561; ENSG00000284598 GeneID; 374768; - KEGG; hsa:374768; - UCSC; uc002ggv.3; human CTD; 374768; - EuPathDB; HostDB:ENSG00000181323.7; - GeneCards; SPEM1; - HGNC; HGNC:32429; SPEM1 MIM; 615116; gene neXtProt; NX_Q8N4L4; - OpenTargets; ENSG00000181323; - PharmGKB; PA162404476; - eggNOG; ENOG410J2CE; Eukaryota eggNOG; ENOG41118KW; LUCA GeneTree; ENSGT00510000049389; - HOGENOM; HOG000154380; - HOVERGEN; HBG108506; - InParanoid; Q8N4L4; - OMA; AWAPDTD; - OrthoDB; EOG091G0L7A; - PhylomeDB; Q8N4L4; - TreeFam; TF338031; - GenomeRNAi; 374768; - PRO; PR:Q8N4L4; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000181323; - CleanEx; HS_SPEM1; - Genevisible; Q8N4L4; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl GO; GO:0007291; P:sperm individualization; IEA:Ensembl InterPro; IPR031368; SPEM1_N Pfam; PF15670; Spem1; 1 2: Evidence at transcript level; Coiled coil; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Membrane; Reference proteome; Spermatogenesis; Transmembrane; Transmembrane helix CHAIN 1 309 Spermatid maturation protein 1 /FTId=PRO_0000307806 TRANSMEM 29 49 Helical. COILED 259 285 COMPBIAS 209 214 Poly-Pro SEQUENCE 309 AA; 34773 MW; 55C2CAD33C8670E0 CRC64; MAMVERPRPE WASYHNCNSN SCQDLGNSVL LLLGLIICIN ISINIVTLLW SRFRGVLYQV FHDTICEKEA PKSSLLRKQT QPPKKQSSPA VHLRCTMDPV MMTVSPPPAH RHRRRGSPTR CAHCPVAWAP DTDDEKPHQY PAICSYHWDV PEDWEGFQHT QGTWVPWSQD APESPPQTIR FQPTVEERPL KTGIWSELGL RAYVYPVNPP PPSPEAPSHK NGGEGAVPEA EAAQYQPVPA PTLGPAVIPE FSRHRSSGRI VYDARDMRRR LRELTREVEA LSGCYPLASG SSTAEETSKN WVYRSLTGR
Research Areas
Citations (0)

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SPEM1 is required for proper cytoplasm removal during spermatogenesis (By similarity).


Zheng, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(16):6852-6857(2007)

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Cat# AP16687c
(40 western blots)
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