|Application ||WB, E|
|Antigen Region||115-143 aa|
|Other Names||Spermatid maturation protein 1, SPEM1, C17orf83|
|Target/Specificity||This SPEM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the Central region of human SPEM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPEM1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for proper cytoplasm removal during spermatogenesis.|
|Cellular Location||Membrane; Single-pass membrane protein. Cytoplasm EMBL; BC033882; AAH33882.1; -; mRNA CCDS; CCDS42254.1; - RefSeq; NP_955371.2; NM_199339.2 UniGene; Hs.710599; - ProteinModelPortal; Q8N4L4; - BioGrid; 131920; 2 IntAct; Q8N4L4; 1 STRING; 9606.ENSP00000315554; - iPTMnet; Q8N4L4; - PhosphoSitePlus; Q8N4L4; - BioMuta; SPEM1; - DMDM; 74728870; - PaxDb; Q8N4L4; - PeptideAtlas; Q8N4L4; - PRIDE; Q8N4L4; - ProteomicsDB; 71940; - Ensembl; ENST00000323675; ENSP00000315554; ENSG00000181323 Ensembl; ENST00000640564; ENSP00000492561; ENSG00000284598 GeneID; 374768; - KEGG; hsa:374768; - UCSC; uc002ggv.3; human CTD; 374768; - EuPathDB; HostDB:ENSG00000181323.7; - GeneCards; SPEM1; - HGNC; HGNC:32429; SPEM1 MIM; 615116; gene neXtProt; NX_Q8N4L4; - OpenTargets; ENSG00000181323; - PharmGKB; PA162404476; - eggNOG; ENOG410J2CE; Eukaryota eggNOG; ENOG41118KW; LUCA GeneTree; ENSGT00510000049389; - HOGENOM; HOG000154380; - HOVERGEN; HBG108506; - InParanoid; Q8N4L4; - OMA; AWAPDTD; - OrthoDB; EOG091G0L7A; - PhylomeDB; Q8N4L4; - TreeFam; TF338031; - GenomeRNAi; 374768; - PRO; PR:Q8N4L4; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000181323; - CleanEx; HS_SPEM1; - Genevisible; Q8N4L4; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl GO; GO:0007291; P:sperm individualization; IEA:Ensembl InterPro; IPR031368; SPEM1_N Pfam; PF15670; Spem1; 1 2: Evidence at transcript level; Coiled coil; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Membrane; Reference proteome; Spermatogenesis; Transmembrane; Transmembrane helix CHAIN 1 309 Spermatid maturation protein 1 /FTId=PRO_0000307806 TRANSMEM 29 49 Helical. COILED 259 285 COMPBIAS 209 214 Poly-Pro SEQUENCE 309 AA; 34773 MW; 55C2CAD33C8670E0 CRC64; MAMVERPRPE WASYHNCNSN SCQDLGNSVL LLLGLIICIN ISINIVTLLW SRFRGVLYQV FHDTICEKEA PKSSLLRKQT QPPKKQSSPA VHLRCTMDPV MMTVSPPPAH RHRRRGSPTR CAHCPVAWAP DTDDEKPHQY PAICSYHWDV PEDWEGFQHT QGTWVPWSQD APESPPQTIR FQPTVEERPL KTGIWSELGL RAYVYPVNPP PPSPEAPSHK NGGEGAVPEA EAAQYQPVPA PTLGPAVIPE FSRHRSSGRI VYDARDMRRR LRELTREVEA LSGCYPLASG SSTAEETSKN WVYRSLTGR|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SPEM1 is required for proper cytoplasm removal during spermatogenesis (By similarity).
Zheng, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104(16):6852-6857(2007)
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