|Application ||WB, E|
|Other Accession||NP_071372.1, NP_001135446.1|
|Calculated MW||128794 Da|
|Antigen Region||1133-1161 aa|
|Other Names||Probable cation-transporting ATPase 13A2, 363-, ATP13A2, PARK9|
|Target/Specificity||This ATP13A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1133-1161 amino acids from the C-terminal region of human ATP13A2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP13A2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity.|
|Cellular Location||Membrane; Multi-pass membrane protein. Lysosome|
|Tissue Location||Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.
Dos Santos, A.V., et al. Neurosci. Lett. 485(2):121-124(2010)
Reetz, K., et al. Neurobiol. Dis. 39(3):402-408(2010)
Schneider, S.A., et al. Mov. Disord. 25(8):979-984(2010)
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)
Fei, Q.Z., et al. Neurosci. Lett. 475(2):61-63(2010)
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