|Application ||WB, E|
|Other Accession||NP_055443.1, NP_001003690.1|
|Calculated MW||31052 Da|
|Antigen Region||1-30 aa|
|Other Names||MAD2L1-binding protein, Caught by MAD2 protein, MAD2L1BP, CMT2, KIAA0110|
|Target/Specificity||This MAD2L1BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MAD2L1BP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAD2L1BP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Yun, M., et al. Mol. Cancer Res. 7(3):371-382(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Yang, M., et al. Cell 131(4):744-755(2007)
Yun, M.Y., et al. Exp. Mol. Med. 39(4):508-513(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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