|Application ||WB, E|
|Calculated MW||134257 Da|
|Antigen Region||133-161 aa|
|Other Names||Zinc finger and BTB domain-containing protein 38, ZBTB38 (HGNC:26636)|
|Target/Specificity||This ZBTB38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-161 amino acids from the N-terminal region of human ZBTB38.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZBTB38 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl- CpG-dependent manner (PubMed:16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA- replication (PubMed:24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=Localizes to chromocenters.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types.
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)
Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Cho, Y.S., et al. Nat. Genet. 41(5):527-534(2009)
Soranzo, N., et al. PLoS Genet. 5 (4), E1000445 (2009) :
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