|Application ||WB, E|
|Calculated MW||38866 Da|
|Antigen Region||215-243 aa|
|Other Names||Cyclin-G2, CCNG2|
|Target/Specificity||This CCNG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the Central region of human CCNG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCNG2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in growth regulation and in negative regulation of cell cycle progession.|
|Tissue Location||High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Choi, M.G., et al. J. Surg. Res. 157(2):168-174(2009)
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
Xu, G., et al. Mol. Biol. Cell 19(11):4968-4979(2008)
Kasukabe, T., et al. Cancer Sci. 99(8):1693-1698(2008)
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