|Application ||WB, E|
|Calculated MW||38866 Da|
|Antigen Region||215-243 aa|
|Other Names||Cyclin-G2, CCNG2|
|Target/Specificity||This CCNG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the Central region of human CCNG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCNG2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in growth regulation and in negative regulation of cell cycle progession.|
|Tissue Location||High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Choi, M.G., et al. J. Surg. Res. 157(2):168-174(2009)
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)
Xu, G., et al. Mol. Biol. Cell 19(11):4968-4979(2008)
Kasukabe, T., et al. Cancer Sci. 99(8):1693-1698(2008)
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