|Application ||WB, FC, E|
|Other Accession||Q95215, O11780, P82198, NP_000349.1|
|Predicted||Mouse, Pig, Rabbit|
|Calculated MW||74681 Da|
|Antigen Region||106-135 aa|
|Other Names||Transforming growth factor-beta-induced protein ig-h3, Beta ig-h3, Kerato-epithelin, RGD-containing collagen-associated protein, RGD-CAP, TGFBI, BIGH3|
|Target/Specificity||This TGFBI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human TGFBI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TGFBI Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Note=May be associated both with microfibrils and with the cell surface|
|Tissue Location||Highly expressed in the corneal epithelium.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Edelstein, S.L., et al. Cornea 29(6):698-700(2010)
Romero, P., et al. Mol. Vis. 16, 1601-1609 (2010) :
Paliwal, P., et al. Mol. Vis. 16, 1429-1438 (2010) :
Yang, J., et al. Mol. Vis. 16, 1186-1193 (2010) :
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