|Application ||WB, E|
|Calculated MW||48080 Da|
|Antigen Region||245-273 aa|
|Other Names||Kaptin, Actin-associated protein 2E4, KPTN|
|Target/Specificity||This KPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-273 amino acids from the Central region of human KPTN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KPTN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for normal neuromorphogenesis. May be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Cell projection, stereocilium. Cell projection, growth cone Note=Perinuclear at the tips of stereocilium in the inner ear Localized at sites of actin polymerization in motile fibroblasts and neuronal growth cones|
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Provided below are standard protocols that you may find useful for product applications.
KPTN may be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Bearer, E.L., et al. Ann. Hum. Genet. 64 (PT 3), 189-196 (2000) :
Bearer, E.L., et al. Eur. J. Cell Biol. 78(2):117-126(1999)
Bearer, E.L. J. Neurosci. 12(3):750-761(1992)
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