|Application ||WB, E|
|Other Accession||NP_001138609.1, NP_001138607.1|
|Calculated MW||87801 Da|
|Antigen Region||744-770 aa|
|Other Names||Carnitine O-palmitoyltransferase 1, muscle isoform, CPT1-M, Carnitine O-palmitoyltransferase I, muscle isoform, CPT I, CPTI-M, Carnitine palmitoyltransferase 1B, Carnitine palmitoyltransferase I-like protein, CPT1B, KIAA1670|
|Target/Specificity||This CPT1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 744-770 amino acids from the C-terminal region of human CPT1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPT1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion outer membrane; Multi-pass membrane protein|
|Tissue Location||Strong expression in heart and skeletal muscle. No expression in liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene.
Matsuo, T., et al. Biochem. Genet. 48 (3-4), 193-201 (2010) :
Miljkovic, I., et al. Obesity (Silver Spring) 17(7):1396-1401(2009)
Miyagawa, T., et al. PLoS ONE 4 (4), E5394 (2009) :
van der Leij, F.R., et al. J. Biol. Chem. 277(30):26994-27005(2002)
Yamazaki, N., et al. J. Biol. Chem. 275(41):31739-31746(2000)
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