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PARG Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PARG Antibody (C-term) AP16714B
    PARG Antibody (C-term) (Cat. #AP16714b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PARG antibody detected the PARG protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86W56
Other Accession NP_003622.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 111110 Da
Antigen Region 821-849 aa
Additional Information
Gene ID 670;8505
Other Names Poly(ADP-ribose) glycohydrolase, PARG
Target/Specificity This PARG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 821-849 amino acids from the C-terminal region of human PARG.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPARG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters.
Cellular Location Isoform 1: Nucleus Note=Colocalizes with PCNA at replication foci. Relocalizes to the cytoplasm in response to DNA damage Isoform 3: Cytoplasm. Isoform 5: Mitochondrion matrix.
Tissue Location Ubiquitously expressed.
Citations (0)

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Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.


Whatcott, C.J., et al. Exp. Cell Res. 315(20):3477-3485(2009)
Frizzell, K.M., et al. J. Biol. Chem. 284(49):33926-33938(2009)
Erdelyi, K., et al. FASEB J. 23(10):3553-3563(2009)
Ame, J.C., et al. J. Cell. Sci. 122 (PT 12), 1990-2002 (2009) :
Uchiumi, F., et al. Genes Cells 13(12):1229-1247(2008)

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Cat# AP16714B
(40 western blots)
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