BFAR Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9NZS9 |
Other Accession | NP_057645.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 52738 Da |
Antigen Region | 1-30 aa |
Gene ID | 51283 |
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Other Names | Bifunctional apoptosis regulator, RING finger protein 47, BFAR, BAR, RNF47 |
Target/Specificity | This BFAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BFAR. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BFAR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BFAR |
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Synonyms | BAR, RNF47 |
Function | Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle. Not expressed in heart, kidney, lung and spleen |
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Provided below are standard protocols that you may find useful for product applications.
Background
BFAR is a apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors.
References
Liu, X., et al. Retina (Philadelphia, Pa.) (2010) In press :
Chua, C.C., et al. Cardiovasc. Res. 81(1):20-27(2009)
Roth, W., et al. Cell Death Differ. 10(10):1178-1187(2003)
Zhang, H., et al. Proc. Natl. Acad. Sci. U.S.A. 97(6):2597-2602(2000)
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