|Application ||WB, E|
|Other Accession||P35525, P51789, NP_001164559.1|
|Calculated MW||98535 Da|
|Antigen Region||209-237 aa|
|Other Names||Chloride channel protein 2, ClC-2, CLCN2|
|Target/Specificity||This CLCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-237 amino acids from the N-terminal region of human CLCN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLCN2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells|
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Provided below are standard protocols that you may find useful for product applications.
The transmembrane protein encoded by this gene is a voltage-gated chloride channel that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
Scheper, G.C., et al. Genet Test Mol Biomarkers 14(2):255-257(2010)
Cornejo, I., et al. J. Cell. Physiol. 221(3):650-657(2009)
Thompson, C.H., et al. J. Biol. Chem. 284(38):26051-26062(2009)
Kleefuss-Lie, A., et al. Nat. Genet. 41(9):954-955(2009)
Klaus, F., et al. Biochem. Biophys. Res. Commun. 381(3):407-411(2009)
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