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CLCN2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P51788 |
| Other Accession | P35525, P51789, NP_001164559.1 |
| Reactivity | Human, Mouse |
| Predicted | Rabbit, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 98535 Da |
| Antigen Region | 209-237 aa |
| Gene ID | 1181 |
|---|---|
| Other Names | Chloride channel protein 2, ClC-2, CLCN2 |
| Target/Specificity | This CLCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-237 amino acids from the N-terminal region of human CLCN2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLCN2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLCN2 |
|---|---|
| Function | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage- gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitously expressed. Moderately expressed in aortic and coronary vascular smooth muscle cells and expressed at a low level in aortic endothelial cells. Expressed in the adrenal gland, predominantly in the zona glomerulosa (PubMed:29403011) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The transmembrane protein encoded by this gene is a voltage-gated chloride channel that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
References
Scheper, G.C., et al. Genet Test Mol Biomarkers 14(2):255-257(2010)
Cornejo, I., et al. J. Cell. Physiol. 221(3):650-657(2009)
Thompson, C.H., et al. J. Biol. Chem. 284(38):26051-26062(2009)
Kleefuss-Lie, A., et al. Nat. Genet. 41(9):954-955(2009)
Klaus, F., et al. Biochem. Biophys. Res. Commun. 381(3):407-411(2009)
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