|Application ||WB, E|
|Other Accession||Q02293, P49355, NP_002019.1|
|Calculated MW||48774 Da|
|Antigen Region||12-40 aa|
|Other Names||Protein farnesyltransferase subunit beta, FTase-beta, CAAX farnesyltransferase subunit beta, Ras proteins prenyltransferase subunit beta, FNTB|
|Target/Specificity||This FNTB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human FNTB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FNTB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X.|
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Provided below are standard protocols that you may find useful for product applications.
FNTB Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
Fontaine-Bisson, B., et al. J. Mol. Med. (2009) In press :
Zhou, J., et al. J. Biol. Chem. 284(15):9648-9655(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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