|Application ||WB, E|
|Other Accession||NP_002838.2, NP_570857.2|
|Calculated MW||111271 Da|
|Antigen Region||161-189 aa|
|Other Names||Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387|
|Target/Specificity||This PTPRN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the N-terminal region of human PTPRN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTPRN2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in development of nervous system and pancreatic endocrine cells.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein|
|Tissue Location||Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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