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DYRK1B Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DYRK1B Antibody (Center) AP16734c
    DYRK1B Antibody (Center) (Cat. #AP16734c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DYRK1B antibody detected the DYRK1B protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y463
Other Accession Q9Z188, NP_004705.1, NP_006474.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 69198 Da
Antigen Region 377-405 aa
Additional Information
Gene ID 9149
Other Names Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Minibrain-related kinase, Mirk protein kinase, DYRK1B, MIRK
Target/Specificity This DYRK1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-405 amino acids from the Central region of human DYRK1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDYRK1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MIRK
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).
Cellular Location Nucleus.
Tissue Location Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
Research Areas
Citations (0)

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DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain. [provided by RefSeq].


Lauth, M., et al. Nat. Struct. Mol. Biol. 17(6):718-725(2010)
Yang, C., et al. Carcinogenesis 31(4):552-558(2010)
Jin, K., et al. J. Biol. Chem. 284(34):22916-22925(2009)
Deng, X., et al. Cancer Res. 69(8):3317-3324(2009)
Janumyan, Y., et al. J. Biol. Chem. 283(49):34108-34120(2008)

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Cat# AP16734c
(40 western blots)
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