|Application ||WB, E|
|Other Accession||Q02527, Q10470, NP_002400.3, NP_001091740.1|
|Calculated MW||61313 Da|
|Antigen Region||426-454 aa|
|Other Names||Beta-1, 4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, GNT-III, GlcNAc-T III, N-acetylglucosaminyltransferase III, MGAT3, GGNT3|
|Target/Specificity||This MGAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 426-454 amino acids from the C-terminal region of human MGAT3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MGAT3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Benson, V., et al. Int. Immunol. 22(3):167-177(2010)
Akasaka-Manya, K., et al. Glycobiology 20(1):99-106(2010)
Pinho, S.S., et al. Hum. Mol. Genet. 18(14):2599-2608(2009)
Sato, Y., et al. J. Biol. Chem. 284(18):11873-11881(2009)
Fiala, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(31):12849-12854(2007)
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