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ARHGEF6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15052 |
| Other Accession | NP_004831.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87499 Da |
| Antigen Region | 614-641 aa |
| Gene ID | 9459 |
|---|---|
| Other Names | Rho guanine nucleotide exchange factor 6, Alpha-Pix, COOL-2, PAK-interacting exchange factor alpha, Rac/Cdc42 guanine nucleotide exchange factor 6, ARHGEF6, COOL2, KIAA0006, PIXA |
| Target/Specificity | This ARHGEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-641 amino acids from the C-terminal region of human ARHGEF6. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARHGEF6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARHGEF6 |
|---|---|
| Synonyms | COOL2, KIAA0006, PIXA |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF). |
| Cellular Location | Cell projection, lamellipodium. |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq].
References
Maiti, A.K. Pharmacogenomics J. 10(2):94-104(2010)
Eriguchi, M., et al. J. Neurol. Sci. 290 (1-2), 80-85 (2010) :
Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
Lim, J.W., et al. Scand. J. Gastroenterol. 44(10):1166-1172(2009)
Baek, H.Y., et al. Ann. N. Y. Acad. Sci. 1096, 18-23 (2007) :
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