|Application ||WB, E|
|Calculated MW||87499 Da|
|Antigen Region||614-641 aa|
|Other Names||Rho guanine nucleotide exchange factor 6, Alpha-Pix, COOL-2, PAK-interacting exchange factor alpha, Rac/Cdc42 guanine nucleotide exchange factor 6, ARHGEF6, COOL2, KIAA0006, PIXA|
|Target/Specificity||This ARHGEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-641 amino acids from the C-terminal region of human ARHGEF6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARHGEF6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||COOL2, KIAA0006, PIXA|
|Function||Acts as a RAC1 guanine nucleotide exchange factor (GEF).|
|Cellular Location||Cell projection, lamellipodium|
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Provided below are standard protocols that you may find useful for product applications.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq].
Maiti, A.K. Pharmacogenomics J. 10(2):94-104(2010)
Eriguchi, M., et al. J. Neurol. Sci. 290 (1-2), 80-85 (2010) :
Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
Lim, J.W., et al. Scand. J. Gastroenterol. 44(10):1166-1172(2009)
Baek, H.Y., et al. Ann. N. Y. Acad. Sci. 1096, 18-23 (2007) :
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