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UBXN8 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - UBXN8 Antibody (N-term) AP16742A
    UBXN8 Antibody (N-term) (Cat. #AP16742a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the UBXN8 antibody detected the UBXN8 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O00124
Other Accession Q2TBH5, NP_005662.1
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 59-87 aa
Additional Information
Other Names UBX domain-containing protein 8, Reproduction 8 protein, Rep-8 protein, UBX domain-containing protein 6, UBXN8, D8S2298E, REP8, UBXD6
Target/Specificity This UBXN8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-87 amino acids from the N-terminal region of human UBXN8.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUBXN8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBXN8
Synonyms D8S2298E, REP8, UBXD6
Function Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Expressed abundantly in ovary and testis, and weakly in all other tissues tested EMBL; D83767; BAA18958.1; -; mRNA EMBL; D83768; BAA18959.1; -; mRNA EMBL; AY302140; AAP57632.1; -; mRNA EMBL; BC020694; AAH20694.1; -; mRNA CCDS; CCDS75723.1; -. [O00124-1] CCDS; CCDS75724.1; -. [O00124-2] CCDS; CCDS75725.1; -. [O00124-3] RefSeq; NP_001269118.1; NM_001282189.1. [O00124-3] RefSeq; NP_001269128.1; NM_001282199.1. [O00124-2] RefSeq; NP_005662.1; NM_005671.3. [O00124-1] UniGene; Hs.153678; - ProteinModelPortal; O00124; - SMR; O00124; - BioGrid; 113702; 26 IntAct; O00124; 10 iPTMnet; O00124; - PhosphoSitePlus; O00124; - EPD; O00124; - MaxQB; O00124; - PeptideAtlas; O00124; - PRIDE; O00124; - ProteomicsDB; 47719; - ProteomicsDB; 47720; -. [O00124-2] ProteomicsDB; 47721; -. [O00124-3] DNASU; 7993; - Ensembl; ENST00000615729; ENSP00000481635; ENSG00000104691. [O00124-3] GeneID; 7993; - KEGG; hsa:7993; - UCSC; uc033bgi.2; human. [O00124-1] CTD; 7993; - EuPathDB; HostDB:ENSG00000104691.14; - GeneCards; UBXN8; - HGNC; HGNC:30307; UBXN8 HPA; HPA017725; - HPA; HPA077538; - MIM; 602155; gene neXtProt; NX_O00124; - OpenTargets; ENSG00000104691; - PharmGKB; PA162408474; - GeneTree; ENSGT00390000018326; - HOGENOM; HOG000132969; - HOVERGEN; HBG010843; - InParanoid; O00124; - PhylomeDB; O00124; - ChiTaRS; UBXN8; human GenomeRNAi; 7993; - PRO; PR:O00124; - Proteomes; UP000005640; Chromosome 8 Bgee; ENSG00000104691; - CleanEx; HS_UBXN8; - ExpressionAtlas; O00124; baseline and differential Genevisible; O00124; HS GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:UniProtKB GO; GO:0005730; C:nucleolus; IDA:HPA GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0007338; P:single fertilization; TAS:ProtInc GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IMP:UniProtKB InterPro; IPR029071; Ubiquitin-like_domsf InterPro; IPR001012; UBX_dom InterPro; IPR017247; UBXN8 Pfam; PF00789; UBX; 1 PIRSF; PIRSF037632; UBX_Rep6; 1 SUPFAM; SSF54236; SSF54236; 1 PROSITE; PS50033; UBX; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 270 UBX domain-containing protein 8 /FTId=PRO_0000211033 TOPO_DOM 1 1 Cytoplasmic. TRANSMEM 2 22 Helical. TOPO_DOM 23 33 Lumenal. TRANSMEM 34 54 Helical. TOPO_DOM 55 270 Cytoplasmic. DOMAIN 187 263 UBX. {ECO:0000255|PROSITE- ProRule:PRU00215} COMPBIAS 71 74 Poly-Glu MOD_RES 167 167 Phosphoserine VAR_SEQ 30 66 Missing (in isoform 3) {ECO:0000303|Ref.2} /FTId=VSP_015535 VAR_SEQ 95 135 Missing (in isoform 2) /FTId=VSP_004376 VARIANT 18 18 V -> M (in dbSNP:rs3174043) /FTId=VAR_052687 VARIANT 51 51 I -> T (in dbSNP:rs2911690) /FTId=VAR_052688 SEQUENCE 270 AA; 30541 MW; 13398A33D0CAC076 CRC64; MASRGVVGIF FLSAVPLVCL ELRRGIPDIG IKDFLLLCGR ILLLLALLTL IISVTTSWLN SFKSPQVYLK EEEEKNEKRQ KLVRKKQQEA QGEKASRYIE NVLKPHQEMK LRKLEERFYQ MTGEAWKLSS GHKLGGDEGT SQTSFETSNR EAAKSQNLPK PLTEFPSPAE QPTCKEIPDL PEEPSQTAEE VVTVALRCPS GNVLRRRFLK SYSSQVLFDW MTRIGYHISL YSLSTSFPRR PLAVEGGQSL EDIGITVDTV LILEEKEQTN
Research Areas
Citations (0)

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Background

UBXN8 may play a role in reproduction.

References

Lamesch, P., et al. Genomics 89(3):307-315(2007)
Yamabe, Y., et al. Genomics 39(2):198-204(1997)

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$ 295.00
$ 99.00
Cat# AP16742A
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(40 western blots)
Availability: In Stock
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