|Application ||WB, E|
|Other Accession||Q3UHK3, NP_055483.2, NP_149081.1|
|Calculated MW||216467 Da|
|Antigen Region||1417-1446 aa|
|Other Names||Protein GREB1, Gene regulated in breast cancer 1 protein, GREB1, KIAA0575|
|Target/Specificity||This GREB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1417-1446 amino acids from the Central region of human GREB1.|
|Precautions||GREB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Expressed in proliferating prostatic tissue and prostate cancer.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq].
Hnatyszyn, H.J., et al. Breast Cancer Res. Treat. 122(2):371-380(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Rittie, L., et al. Arch Dermatol 144(9):1129-1140(2008)
Sun, J., et al. Mol. Endocrinol. 21(11):2651-2662(2007)
Deschenes, J., et al. J. Biol. Chem. 282(24):17335-17339(2007)
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