|Application ||WB, E|
|Other Accession||Q05186, NP_002892.1|
|Calculated MW||38890 Da|
|Antigen Region||305-331 aa|
|Other Names||Reticulocalbin-1, RCN1, RCN|
|Target/Specificity||This RCN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-331 amino acids from the C-terminal region of human RCN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RCN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.|
|Cellular Location||Endoplasmic reticulum lumen.|
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Provided below are standard protocols that you may find useful for product applications.
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.
Favor, J., et al. Genetics 182(4):1077-1088(2009)
Hansen, G.A., et al. Mol. Cell. Biochem. 320 (1-2), 25-33 (2009) :
Cooper, C.R., et al. J. Cell. Biochem. 104(6):2298-2309(2008)
Lim, J., et al. Cell 125(4):801-814(2006)
Taylor, T.D., et al. Nature 440(7083):497-500(2006)
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