|Application ||WB, E|
|Other Accession||Q9D0W5, Q5E992, NP_057143.1|
|Calculated MW||18237 Da|
|Antigen Region||63-91 aa|
|Other Names||Peptidyl-prolyl cis-trans isomerase-like 1, PPIase, Rotamase PPIL1, PPIL1, CYPL1|
|Target/Specificity||This PPIL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the Central region of human PPIL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PPIL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). PPIases accelerate the folding of proteins. It catalyzes the cis- trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:16595688).|
|Tissue Location||Ubiquitous, with the most abundant expression in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Wang, X., et al. J. Biol. Chem. 285(7):4951-4963(2010)
Xu, C., et al. J. Biol. Chem. 281(23):15900-15908(2006)
Xu, C., et al. J. Biomol. NMR 31(2):179-180(2005)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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