|Application ||WB, E|
|Calculated MW||22529 Da|
|Antigen Region||6-34 aa|
|Other Names||Dynactin-associated protein, Full, DYNAP, C18orf26|
|Target/Specificity||This C18orf26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human C18orf26.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C18orf26 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'.|
|Cellular Location||Golgi apparatus membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=Concentrated at cell-cell borders. Localizes at membranes in a microtubule-dependent manner|
|Tissue Location||Expressed in fibroblast and numerous cancer cell lines (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
C18orf26 (chromosome 18 open reading frame 26) is a 210 amino acid single pass membrane protein that is encoded by a gene which maps to human chromosome 18. Chromosome 18 houses over 300 protein-coding genes and contains nearly 76 million nucleotide bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.
Kunoh, T., et al. Mol. Cancer Ther. 9(11):2934-2942(2010)
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