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C18orf26 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N1N2 |
| Other Accession | NP_775900.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22529 Da |
| Antigen Region | 6-34 aa |
| Gene ID | 284254 |
|---|---|
| Other Names | Dynactin-associated protein, Full, DYNAP, C18orf26 |
| Target/Specificity | This C18orf26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human C18orf26. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C18orf26 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DYNAP |
|---|---|
| Synonyms | C18orf26 |
| Function | Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'. |
| Cellular Location | Golgi apparatus membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note=Concentrated at cell-cell borders Localizes at membranes in a microtubule-dependent manner |
| Tissue Location | Expressed in fibroblast and numerous cancer cell lines (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
C18orf26 (chromosome 18 open reading frame 26) is a 210 amino acid single pass membrane protein that is encoded by a gene which maps to human chromosome 18. Chromosome 18 houses over 300 protein-coding genes and contains nearly 76 million nucleotide bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.
References
Kunoh, T., et al. Mol. Cancer Ther. 9(11):2934-2942(2010)
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