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NCAPD3 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NCAPD3 Antibody (C-term) AP16786B
    NCAPD3 Antibody (C-term) (Cat. #AP16786b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the NCAPD3 antibody detected the NCAPD3 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P42695
Other Accession NP_056076.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 168891 Da
Antigen Region 1050-1078 aa
Additional Information
Gene ID 23310
Other Names Condensin-2 complex subunit D3, Non-SMC condensin II complex subunit D3, hCAP-D3, NCAPD3, CAPD3, KIAA0056
Target/Specificity This NCAPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1050-1078 amino acids from the C-terminal region of human NCAPD3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNCAPD3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCAPD3 {ECO:0000303|PubMed:27737959, ECO:0000312|HGNC:HGNC:28952}
Function Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).
Cellular Location Nucleus.
Research Areas
Citations (0)
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Background

Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Takemoto, A., et al. Nat. Struct. Mol. Biol. 16(12):1302-1308(2009)
Lapointe, J., et al. Am. J. Surg. Pathol. 32(2):205-209(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007) :

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$ 365.00
$ 140.00
Cat# AP16786B
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