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NCAPD3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NCAPD3 Antibody (C-term) AP16786B
    NCAPD3 Antibody (C-term) (Cat. #AP16786b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the NCAPD3 antibody detected the NCAPD3 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P42695
Other Accession NP_056076.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 1050-1078 aa
Additional Information
Other Names Condensin-2 complex subunit D3, Non-SMC condensin II complex subunit D3, hCAP-D3, NCAPD3, CAPD3, KIAA0056
Target/Specificity This NCAPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1050-1078 amino acids from the C-terminal region of human NCAPD3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNCAPD3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCAPD3
Synonyms CAPD3, KIAA0056
Function Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.
Cellular Location Nucleus. EMBL; D29954; BAA06224.1; -; mRNA EMBL; AP001775; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471065; EAW67824.1; -; Genomic_DNA EMBL; BC098398; AAH98398.1; -; mRNA EMBL; AF070553; AAC28639.1; -; mRNA CCDS; CCDS31723.1; - RefSeq; NP_056076.1; NM_015261.2 UniGene; Hs.438550; - ProteinModelPortal; P42695; - BioGrid; 116902; 64 ComplexPortal; CPX-985; Condensin II complex CORUM; P42695; - DIP; DIP-43903N; - IntAct; P42695; 22 MINT; P42695; - STRING; 9606.ENSP00000433681; - iPTMnet; P42695; - PhosphoSitePlus; P42695; - BioMuta; NCAPD3; - DMDM; 82654946; - EPD; P42695; - MaxQB; P42695; - PaxDb; P42695; - PeptideAtlas; P42695; - PRIDE; P42695; - ProteomicsDB; 55540; - DNASU; 23310; - Ensembl; ENST00000534548; ENSP00000433681; ENSG00000151503 GeneID; 23310; - KEGG; hsa:23310; - UCSC; uc001qhd.2; human CTD; 23310; - DisGeNET; 23310; - EuPathDB; HostDB:ENSG00000151503.12; - GeneCards; NCAPD3; - HGNC; HGNC:28952; NCAPD3 HPA; HPA040286; - MIM; 609276; gene neXtProt; NX_P42695; - OpenTargets; ENSG00000151503; - PharmGKB; PA162397090; - eggNOG; KOG0413; Eukaryota eggNOG; ENOG410XSGK; LUCA GeneTree; ENSGT00390000011258; - HOGENOM; HOG000111840; - HOVERGEN; HBG061537; - InParanoid; P42695; - KO; K11491; - OMA; RAHAIIT; - OrthoDB; EOG091G00PU; - PhylomeDB; P42695; - TreeFam; TF101162; - Reactome; R-HSA-2299718; Condensation of Prophase Chromosomes ChiTaRS; NCAPD3; human GeneWiki; NCAPD3; - GenomeRNAi; 23310; - PRO; PR:P42695; - Proteomes; UP000005640; Chromosome 11 Bgee; ENSG00000151503; - CleanEx; HS_NCAPD3; - ExpressionAtlas; P42695; baseline and differential Genevisible; P42695; HS GO; GO:0000779; C:condensed chromosome, centromeric region; IBA:GO_Central GO; GO:0016020; C:membrane; HDA:UniProtKB GO; GO:0000799; C:nuclear condensin complex; IDA:UniProtKB GO; GO:0031618; C:nuclear pericentric heterochromatin; IDA:BHF-UCL GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0003682; F:chromatin binding; IBA:GO_Central GO; GO:0035064; F:methylated histone binding; IDA:UniProtKB GO; GO:0051301; P:cell division; IEA:UniProtKB-KW GO; GO:0051304; P:chromosome separation; IBA:GO_Central GO; GO:0010032; P:meiotic chromosome condensation; IBA:GO_Central GO; GO:0007076; P:mitotic chromosome condensation; IDA:UniProtKB InterPro; IPR016024; ARM-type_fold InterPro; IPR026971; CND1/NCAPD3 InterPro; IPR032682; Cnd1_C InterPro; IPR012371; NCAPD3 PANTHER; PTHR14222; PTHR14222; 1 Pfam; PF12717; Cnd1; 1 PIRSF; PIRSF036508; Condns_HCP-6; 1 SUPFAM; SSF48371; SSF48371; 4 1: Evidence at protein level; Cell cycle; Cell division; Coiled coil; Complete proteome; DNA condensation; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat CHAIN 1 1498 Condensin-2 complex subunit D3 /FTId=PRO_0000050716 REPEAT 441 475 HEAT 1 REPEAT 537 572 HEAT 2 REPEAT 579 610 HEAT 3 REPEAT 973 1009 HEAT 4 COILED 1219 1275 MOD_RES 567 567 Phosphoserine MOD_RES 1329 1329 Phosphoserine MOD_RES 1331 1331 Phosphothreonine MOD_RES 1348 1348 Phosphoserine MOD_RES 1357 1357 Phosphoserine MOD_RES 1372 1372 Phosphoserine MOD_RES 1379 1379 Phosphothreonine MOD_RES 1382 1382 Phosphoserine MOD_RES 1384 1384 Phosphoserine VARIANT 622 622 R -> Q (in dbSNP:rs12292394) /FTId=VAR_053043 VARIANT 907 907 P -> T (in dbSNP:rs34739733) /FTId=VAR_053044 VARIANT 1034 1034 S -> R (in dbSNP:rs7927108) /FTId=VAR_053045 SEQUENCE 1498 AA; 168891 MW; 038033DA393E4310 CRC64; MVALRGLGSG LQPWCPLDLR LEWVDTVWEL DFTETEPLDP SIEAEIIETG LAAFTKLYES LLPFATGEHG SMESIWTFFI ENNVSHSTLV ALFYHFVQIV HKKNVSVQYR EYGLHAAGLY FLLLEVPGSV ANQVFHPVMF DKCIQTLKKS WPQESNLNRK RKKEQPKSSQ ANPGRHRKRG KPPRREDIEM DEIIEEQEDE NICFSARDLS QIRNAIFHLL KNFLRLLPKF SLKEKPQCVQ NCIEVFVSLT NFEPVLHECH VTQARALNQA KYIPELAYYG LYLLCSPIHG EGDKVISCVF HQMLSVILML EVGEGSHRAP LAVTSQVINC RNQAVQFISA LVDELKESIF PVVRILLQHI CAKVVDKSEY RTFAAQSLVQ LLSKLPCGEY AMFIAWLYKY SRSSKIPHRV FTLDVVLALL ELPEREVDNT LSLEHQKFLK HKFLVQEIMF DRCLDKAPTV RSKALSSFAH CLELTVTSAS ESILELLINS PTFSVIESHP GTLLRNSSAF SYQRQTSNRS EPSGEINIDS SGETVGSGER CVMAMLRRRI RDEKTNVRKS ALQVLVSILK HCDVSGMKED LWILQDQCRD PAVSVRKQAL QSLTELLMAQ PRCVQIQKAW LRGVVPVVMD CESTVQEKAL EFLDQLLLQN IRHHSHFHSG DDSQVLAWAL LTLLTTESQE LSRYLNKAFH IWSKKEKFSP TFINNVISHT GTEHSAPAWM LLSKIAGSSP RLDYSRIIQS WEKISSQQNP NSNTLGHILC VIGHIAKHLP KSTRDKVTDA VKCKLNGFQW SLEVISSAVD ALQRLCRASA ETPAEEQELL TQVCGDVLST CEHRLSNIVL KENGTGNMDE DLLVKYIFTL GDIAQLCPAR VEKRIFLLIQ SVLASSADAD HSPSSQGSSE APASQPPPQV RGSVMPSVIR AHAIITLGKL CLQHEDLAKK SIPALVRELE VCEDVAVRNN VIIVMCDLCI RYTIMVDKYI PNISMCLKDS DPFIRKQTLI LLTNLLQEEF VKWKGSLFFR FVSTLIDSHP DIASFGEFCL AHLLLKRNPV MFFQHFIECI FHFNNYEKHE KYNKFPQSER EKRLFSLKGK SNKERRMKIY KFLLEHFTDE QRFNITSKIC LSILACFADG ILPLDLDASE LLSDTFEVLS SKEIKLLAMR SKPDKDLLME EDDMALANVV MQEAQKKLIS QVQKRNFIEN IIPIIISLKT VLEKNKIPAL RELMHYLREV MQDYRDELKD FFAVDKQLAS ELEYDMKKYQ EQLVQEQELA KHADVAGTAG GAEVAPVAQV ALCLETVPVP AGQENPAMSP AVSQPCTPRA SAGHVAVSSP TPETGPLQRL LPKARPMSLS TIAILNSVKK AVESKSRHRS RSLGVLPFTL NSGSPEKTCS QVSSYSLEQE SNGEIEHVTK RAISTPEKSI SDVTFGAGVS YIGTPRTPSS AKEKIEGRSQ GNDILCLSLP DKPPPQPQQW NVRSPARNKD TPACSRRSLR KTPLKTAN
Research Areas
Citations (0)

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Background

Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Takemoto, A., et al. Nat. Struct. Mol. Biol. 16(12):1302-1308(2009)
Lapointe, J., et al. Am. J. Surg. Pathol. 32(2):205-209(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007) :

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$ 295.00
$ 99.00
Cat# AP16786B
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(40 western blots)
Availability: In Stock
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