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SIT1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y3P8 |
| Other Accession | Q5M869, NP_055265.1 |
| Reactivity | Human |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21126 Da |
| Antigen Region | 161-189 aa |
| Gene ID | 27240 |
|---|---|
| Other Names | Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transmembrane adapter protein, Suppression-inducing transmembrane adapter 1, gp30/40, SIT1, SIT |
| Target/Specificity | This SIT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the C-terminal region of human SIT1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SIT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIT1 |
|---|---|
| Synonyms | SIT |
| Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level) Expressed in T- and B-cell lymphoma. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
References
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Tedoldi, S., et al. Blood 107(1):213-221(2006)
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
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