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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   RCAN1 Antibody (N-term)   

RCAN1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RCAN1 Antibody (N-term) AP16791A
    RCAN1 Antibody (N-term) (Cat. #AP16791a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RCAN1 antibody detected the RCAN1 protein (arrow).
  • WB - RCAN1 Antibody (N-term) AP16791A
    Western blot analysis of RCAN1 (arrow) using rabbit polyclonal RCAN1 Antibody (N-term) (Cat. #AP16791a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the RCAN1 gene.
  • IF - RCAN1 Antibody (N-term) AP16791A
    Fluorescent confocal image of A431 cell stained with RCAN1 Antibody (N-term)(Cat#AP16791a).A431 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with RCAN1 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃). Nuclei were counterstained with DAPI (blue) (10 µg/ml, 10 min). RCAN1 immunoreactivity is localized to Cytoplasm significantly.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P53805
Other Accession Q9JHG6, NP_004405.3, NP_981963.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28079 Da
Antigen Region 41-68 aa
Additional Information
Gene ID 1827
Other Names Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1
Target/Specificity This RCAN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-68 amino acids from the N-terminal region of human RCAN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRCAN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCAN1
Synonyms ADAPT78, CSP1, DSC1, DSCR1
Function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Tissue Location Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues
Research Areas
Citations (0)

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The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Tam, G.W., et al. Biochem. Soc. Trans. 38(2):445-451(2010)
Lee, M.Y., et al. Hum. Mol. Genet. 19(3):468-479(2010)
Sales, K.J., et al. Am. J. Pathol. 176(1):435-445(2010)
Sales, K.J., et al. Biochim. Biophys. Acta 1793(12):1917-1928(2009)

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$ 295.00
$ 99.00
Cat# AP16791A
(40 western blots)
Availability: In Stock
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