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RCAN1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P53805 |
| Other Accession | Q9JHG6, NP_004405.3, NP_981963.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28079 Da |
| Antigen Region | 41-68 aa |
| Gene ID | 1827 |
|---|---|
| Other Names | Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Regulator of calcineurin 1, RCAN1, ADAPT78, CSP1, DSC1, DSCR1 |
| Target/Specificity | This RCAN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-68 amino acids from the N-terminal region of human RCAN1. |
| Dilution | IF~~1:10~50 WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RCAN1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RCAN1 |
|---|---|
| Synonyms | ADAPT78, CSP1, DSC1, DSCR1 |
| Function | Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). |
| Tissue Location | Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Tam, G.W., et al. Biochem. Soc. Trans. 38(2):445-451(2010)
Lee, M.Y., et al. Hum. Mol. Genet. 19(3):468-479(2010)
Sales, K.J., et al. Am. J. Pathol. 176(1):435-445(2010)
Sales, K.J., et al. Biochim. Biophys. Acta 1793(12):1917-1928(2009)
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