|Application ||WB, E|
|Other Accession||P61212, P61211, Q2YDM1, NP_001168.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||20418 Da|
|Antigen Region||81-108 aa|
|Other Names||ADP-ribosylation factor-like protein 1, ARL1|
|Target/Specificity||This ARL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-108 amino acids from the Central region of human ARL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.|
|Cellular Location||Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Lipid- anchor|
|Tissue Location||Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
Houghton, F.J., et al. Cell 138(4):787-794(2009)
Nishimoto-Morita, K., et al. J. Biol. Chem. 284(16):10583-10592(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Zahn, C., et al. Mol. Membr. Biol. 23(6):475-485(2006)
Lu, L., et al. Mol. Biol. Cell 15(10):4426-4443(2004)
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