|Application ||WB, E|
|Other Accession||P61212, P61211, Q2YDM1, NP_001168.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||20418 Da|
|Antigen Region||81-108 aa|
|Other Names||ADP-ribosylation factor-like protein 1, ARL1|
|Target/Specificity||This ARL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-108 amino acids from the Central region of human ARL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.|
|Cellular Location||Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
Houghton, F.J., et al. Cell 138(4):787-794(2009)
Nishimoto-Morita, K., et al. J. Biol. Chem. 284(16):10583-10592(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Zahn, C., et al. Mol. Membr. Biol. 23(6):475-485(2006)
Lu, L., et al. Mol. Biol. Cell 15(10):4426-4443(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.