|Application ||WB, E|
|Other Accession||Q63572, NP_006276.2|
|Calculated MW||67684 Da|
|Antigen Region||187-215 aa|
|Other Names||Dual specificity testis-specific protein kinase 1, Testicular protein kinase 1, TESK1|
|Target/Specificity||This TESK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-215 amino acids from the Central region of human TESK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TESK1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Johne, C., et al. Mol. Biol. Cell 19(4):1391-1403(2008)
LaLonde, D.P., et al. J. Biol. Chem. 280(22):21680-21688(2005)
Leeksma, O.C., et al. Eur. J. Biochem. 269(10):2546-2556(2002)
Toshima, J.Y., et al. J. Biol. Chem. 276(46):43471-43481(2001)
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