|Application ||WB, E|
|Calculated MW||43779 Da|
|Antigen Region||69-96 aa|
|Other Names||Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, Testis-specific androgen-binding protein, ABP, Testosterone-estradiol-binding globulin, TeBG, Testosterone-estrogen-binding globulin, SHBG|
|Target/Specificity||This SHBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-96 amino acids from the N-terminal region of human SHBG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SHBG Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.|
|Cellular Location||Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis|
|Tissue Location||Isoform 1 and isoform 2 are present in liver and testis|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene.
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Xita, N., et al. Exp. Clin. Endocrinol. Diabetes (2010) In press :
Diaz, M., et al. Fertil. Steril. (2010) In press :
Hatzi, E., et al. Gynecol. Endocrinol. (2010) In press :
Iwasaki, M., et al. Nutr Cancer 62(4):466-475(2010)
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