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ATL1 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP16799b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP16799b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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- Backgrounds
ATL1 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q8WXF7 |
| Other Accession | Q6PST4, Q8BH66, Q60HD2, Q58D72, NP_001121185.1, NP_056999.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Monkey, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 63544 Da |
ATL1 Antibody (C-term) - Additional info | |
| Gene ID 51062 | |
| Other Names ATL1; GBP3; SPG3A; Atlastin-1; Brain-specific GTP-binding protein; GTP-binding protein 3; Guanine nucleotide-binding protein 3; Spastic paraplegia 3 protein A | |
| Target/Specificity This ATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-504 amino acids from the C-terminal region of human ATL1. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ATL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ATL1 Antibody (C-term) - Protein Information | |
| Name ATL1 | |
| Synonyms GBP3, SPG3A | |
| Function GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | |
| Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, axon (By similarity) | |
| Tissue Location Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain Expressed in upper and lower motor neurons (at protein level) | |
ATL1 Antibody (C-term) - Related products
AP16799b: ATL1 Antibody (C-term)
DC02985: Human ATL1 cDNA Clone
ATL1 Antibody (C-term) - Application data
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ATL1 Antibody (C-term) (Cat. #AP16799b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ATL1 antibody detected the ATL1 protein (arrow).
ATL1 Antibody (C-term) - Research Areas
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BACKGROUND
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
REFERENCES
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010) Park, S.H., et al. J. Clin. Invest. 120(4):1097-1110(2010) Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010) de Leva, M.F., et al. J. Neurol. 257(3):328-331(2010) Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
