|Application ||WB, E|
|Other Accession||Q6PST4, Q8BH66, Q60HD2, Q58D72, NP_001121185.1, NP_056999.2|
|Predicted||Bovine, Monkey, Mouse, Rat|
|Calculated MW||63544 Da|
|Antigen Region||477-504 aa|
|Other Names||Atlastin-1, 365-, Brain-specific GTP-binding protein, GTP-binding protein 3, GBP-3, hGBP3, Guanine nucleotide-binding protein 3, Spastic paraplegia 3 protein A, ATL1, GBP3, SPG3A|
|Target/Specificity||This ATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-504 amino acids from the C-terminal region of human ATL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, axon|
|Tissue Location||Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain Expressed in upper and lower motor neurons (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Park, S.H., et al. J. Clin. Invest. 120(4):1097-1110(2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
de Leva, M.F., et al. J. Neurol. 257(3):328-331(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
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