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PIGP Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PIGP Antibody (N-term) AP16809a
    PIGP Antibody (N-term) (Cat. #AP16809a) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the PIGP antibody detected the PIGP protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P57054
Other Accession NP_710148.1, NP_710149.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 18059 Da
Antigen Region 2-30 aa
Additional Information
Gene ID 51227
Other Names Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5, Down syndrome critical region protein C, Phosphatidylinositol-glycan biosynthesis class P protein, PIG-P, PIGP, DCRC, DSCR5, DSCRC
Target/Specificity This PIGP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human PIGP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPIGP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIGP
Synonyms DCRC, DSCR5, DSCRC
Function Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ferrando-Miguel, R., et al. Amino Acids 26(3):255-261(2004)
Choi, D.K., et al. Mamm. Genome 12(5):347-351(2001)
Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
Watanabe, R., et al. EMBO J. 19(16):4402-4411(2000)

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Cat# AP16809a
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(40 western blots)
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