|Application ||WB, E|
|Other Accession||NP_710148.1, NP_710149.1|
|Calculated MW||18059 Da|
|Antigen Region||2-30 aa|
|Other Names||Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5, Down syndrome critical region protein C, Phosphatidylinositol-glycan biosynthesis class P protein, PIG-P, PIGP, DCRC, DSCR5, DSCRC|
|Target/Specificity||This PIGP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human PIGP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIGP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DCRC, DSCR5, DSCRC|
|Function||Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ferrando-Miguel, R., et al. Amino Acids 26(3):255-261(2004)
Choi, D.K., et al. Mamm. Genome 12(5):347-351(2001)
Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
Watanabe, R., et al. EMBO J. 19(16):4402-4411(2000)
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