|Application ||WB, E|
|Calculated MW||58252 Da|
|Antigen Region||350-377 aa|
|Other Names||RCC1 and BTB domain-containing protein 1, Chronic lymphocytic leukemia deletion region gene 7 protein, CLL deletion region gene 7 protein, Regulator of chromosome condensation and BTB domain-containing protein 1, RCBTB1, CLLD7, E45|
|Target/Specificity||This RCBTB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-377 amino acids from the Central region of human RCBTB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RCBTB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in cell cycle regulation by chromatin remodeling.|
|Tissue Location||Ubiquitously expressed (PubMed:11306461, PubMed:27486781). In the retina, present in the nerve fiber layer and to a lesser extent in the inner and outer plexiform layers (at protein level) (PubMed:27486781).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies.
Genuneit, J., et al. Clin. Exp. Allergy 39(12):1875-1888(2009)
Guo, D.F., et al. J. Biol. Chem. 279(20):21109-21120(2004)
Dunham, A., et al. Nature 428(6982):522-528(2004)
Solomou, E.E., et al. Leuk. Lymphoma 44(9):1579-1585(2003)
Mabuchi, H., et al. Cancer Res. 61(7):2870-2877(2001)
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