|Application ||WB, E|
|Other Accession||P70669, NP_000435.3|
|Calculated MW||86474 Da|
|Antigen Region||567-595 aa|
|Other Names||Phosphate-regulating neutral endopeptidase, 3424-, Metalloendopeptidase homolog PEX, Vitamin D-resistant hypophosphatemic rickets protein, X-linked hypophosphatemia protein, HYP, PHEX, PEX|
|Target/Specificity||This PHEX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the C-terminal region of human PHEX.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PHEX Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in bone and dentin mineralization and renal phosphate reabsorption.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Lymphocytes and fetal brain; not in adult brain, placenta, skeletal muscle and pancreas; not in adult and fetal heart, lung, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets.
Majewski, P.M., et al. J. Biol. Chem. 285(45):34828-34838(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Clausmeyer, S., et al. Calcif. Tissue Int. 85(3):211-220(2009)
Gaucher, C., et al. Hum. Genet. 125(4):401-411(2009)
Strom, T.M., et al. Curr. Opin. Nephrol. Hypertens. 17(4):357-362(2008)
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